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Fig. 8 | Inflammation and Regeneration

Fig. 8

From: Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration

Fig. 8

Schematic representation. Atypical cholangiocytes in ductular reaction (DR) can be derived from hepatocyte-cholangiocyte transdifferentiation (HCT). HCT mediated by the COX-2-TGF-β-TGFBR1-β-catenin-TCF4 pathway misguided liver regeneration with maldevelopment of the bile drainage system and bile acid homeostasis disequilibrium. The secondary strike of chronic liver injury can be ameliorated by the inhibition of COX-2

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Inflammation and Regeneration

ISSN: 1880-8190

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