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Fig. 6 | Inflammation and Regeneration

Fig. 6

From: CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model

Fig. 6

The effects of CX3CL1 and PLX3397 intervention on retinal microglia and RGCs. A Western blot analysis and densitometry quantification of CX3CR1, CD68, and Iba-1 expressions within mouse retina in sham-operation, ONT + PBS + DMSO, ONT + CX3CL1 injection, ONT + PLX3397 injection groups (n = 6). B Western blot analysis and densitometry quantification of βIII-Tubulin, BRN3A, and GAP-43 expressions within mouse retina in sham-operation, ONT + PBS + DMSO, ONT + CX3CL1 injection, ONT + PLX3397 injection groups (n = 6). C mRNA expressions of CX3CR1, CD68, Iba-1, βIII-Tubulin, BRN3A, and GAP-43 within mouse retina in sham-operation, ONT + PBS + DMSO, ONT + CX3CL1 injection, ONT + PLX3397 injection groups (n = 6). D Labeling of βIII-Tubulin in mouse retina of sham-operation, ONT + PBS + DMSO, ONT + CX3CL1 injection, ONT + PLX3397 injection groups. Representative images depict the immunohistochemistry for RGCs and their axons labeled by βIII-Tubulin. Magnification 400, scale bar = 50 μm. Bars indicate the mean, while error bars show the standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Inflammation and Regeneration

ISSN: 1880-8190

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