Skip to main content
Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers

Fig. 3

Induction of IGF2 expression in AT2s by treatment with TSE. A Representative H&E or immunohistochemistry (IHC) images showing airspace enlargement and changes in the expression of IGF1, IGF2, IR, and IGF-1R after treatment with TSE for 12 months. B Representative immunofluorescence images and quantitative analyses showing increases in the IGF2 expression in SPC+ AT2s (IGF2+SPC+ cells) by exposure to TSE for 12 months (n = 5 or 8/group). Data are the mean ± SD. ***p < 0.001 (two-tailed Student’s t-test). Scale bars: 25 μm (A, H&E images); 100 μm (A, IHC images); 50 μm (B); 10 μm (B, insets)

Back to article page

Inflammation and Regeneration

ISSN: 1880-8190

Contact us