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Fig. 4 | Inflammation and Regeneration

Fig. 4

From: Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers

Fig. 4

Attenuation of NB-induced emphysematous features by Insr knockout in type II alveolar epithelial cells. A Schematic diagram of the experimental procedure. B Representative H&E and immunofluorescence (IF) images of changes in the level of Pdpn+ AT1s and SPC+ AT2s, the proliferation of AT2s (Ki67+ in Muc1+ AT2s), and airspace enlargement. C Quantitative analyses of changes in the level of Pdpn+ AT1s and the proliferation of AT2s (Ki67+ in Muc1+ AT2s) (n = 11‒17/group). D Quantitative analysis of airspace enlargement (n = 11/group). E Changes in lung function (n = 6/group). Data are the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001 (one-way ANOVA with Dunnett’s post-hoc test). Scale bars: 25 μm (B, H&E images); 50 μm (B, IF images)

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Inflammation and Regeneration

ISSN: 1880-8190

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