Fig. 3

Multinucleated cells share transcription products within a single cell. A parabiosis experiment was conducted with a mouse expressing Cre under the control of the Ctsk gene and a tdTomato reporter mouse. When their circulations are shared, cells differentiate into tdTomato-expressing osteoclasts through cell-cell fusion. This occurs because the Cre protein induces recombination between loxP sites, resulting in the elimination of the STOP sequence. This demonstrates that multinucleated cells share transcription products within a single cell. Scale bar, 10μm