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Fig. 12 | Inflammation and Regeneration

Fig. 12

From: Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling

Fig. 12

Graphical abstract. Synovial inflammation induced by carrageenan injection causes macrophages to release Nampt and Spp1 to Mki67+ synovial mesenchymal stem cells (MSCs). The synovial MSCs release Ccl7, Spp1, and Csf1 to macrophages. As a result, synovial MSCs increase in number and show activation of extracellular matrix organization and anabolic pathways of metabolism. Macrophage depletion by clodronate liposomes downregulated these signals, leading to a lack of synovial MSC activation

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Inflammation and Regeneration

ISSN: 1880-8190

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