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Fig. 8 | Inflammation and Regeneration

Fig. 8

From: Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling

Fig. 8

Single-cell RNA sequencing of synovial cells from the control and clodronate groups. A Uniform manifold approximation and projection (UMAP) plot showing synovial cell clusters after the cell type annotation. B UMAP plot showing SF subsets. C Violin plot showing the expression pattern of marker genes in each SF subset. D Dotplot showing gene ontology analysis of differentially expressed genes that are highly expressed in each SF cluster. E Proportional breakdown of each SF subset in each condition. F Pseudotime trajectory analysis of SF subsets using monocle3 and slingshot. The black line shows the trajectory plot of cell fates

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