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  3. Dormant chemotherapy-resistant leukemia cells can survive for an extended period before relapse. Nevertheless, the mechanisms underlying the development of chemoresistance in vivo remain unclear.

    Authors: Maho Morimatsu, Erika Yamashita, Shigeto Seno, Takao Sudo, Junichi Kikuta, Hiroki Mizuno, Daisuke Okuzaki, Daisuke Motooka and Masaru Ishii
    Citation: Inflammation and Regeneration 2020 40:15
    Content type: Research article Published on:

  5. The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has ...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takahiro Iwasawa, Masaru Kumagai, Takeki Sato, Satoko Motegi, Yui Ishii, Youhei Koseki, Kei Tomiyoshi, Kazuki Natsui, Nobutaka Takeda, Yuki Yoshida, Fusako Yamazaki, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura…
    Citation: Inflammation and Regeneration 2020 40:14
    Content type: Review Published on:

  8. Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease ...

    Authors: Yoshitaka Kase, Takuya Shimazaki and Hideyuki Okano
    Citation: Inflammation and Regeneration 2020 40:10
    Content type: Review Published on:

  10. Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a decade ago. Although iPSCs...

    Authors: Tomoaki Ishida, Shu Nakao, Tomoe Ueyama, Yukihiro Harada and Teruhisa Kawamura
    Citation: Inflammation and Regeneration 2020 40:8
    Content type: Review Published on:

  14. Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions i...

    Authors: Naoki Hosen
    Citation: Inflammation and Regeneration 2020 40:4
    Content type: Review Published on:

  16. Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signalin...

    Authors: Takehito Ono, Mikihito Hayashi, Fumiyuki Sasaki and Tomoki Nakashima
    Citation: Inflammation and Regeneration 2020 40:2
    Content type: Review Published on:

  17. Heart transplantation (HT) is the only radical treatment available for patients with end-stage heart failure that is refractory to optimal medical treatment and device therapies. However, HT as a therapeutic o...

    Authors: Yoshikazu Kishino, Jun Fujita, Shugo Tohyama, Marina Okada, Sho Tanosaki, Shota Someya and Keiichi Fukuda
    Citation: Inflammation and Regeneration 2020 40:1
    Content type: Review Published on:

  18. Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has f...

    Authors: Yutaka Kuroda, Toshiyuki Kawai, Koji Goto and Shuichi Matsuda
    Citation: Inflammation and Regeneration 2019 39:20
    Content type: Review Published on:

  20. Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its l...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Tomoaki Yoshida, Shunsuke Nojiri, Masahiro Ogawa and Shuji Terai
    Citation: Inflammation and Regeneration 2019 39:18
    Content type: Review Published on:

  21. Induced pluripotent stem cells (iPSCs) can be produced from various somatic cells and have the ability to differentiate into various cells and tissues of the body. Regenerative medicine using iPSCs is expected...

    Authors: Masafumi Umekage, Yoshiko Sato and Naoko Takasu
    Citation: Inflammation and Regeneration 2019 39:17
    Content type: Review Published on:

  25. Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential a...

    Authors: Tomoko Yamaguchi, Juntaro Matsuzaki, Takeshi Katsuda, Yoshimasa Saito, Hidetsugu Saito and Takahiro Ochiya
    Citation: Inflammation and Regeneration 2019 39:13
    Content type: Review Published on:

  26. Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 fam...

    Authors: Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Shinnosuke Morikawa and Junya Masumoto
    Citation: Inflammation and Regeneration 2019 39:12
    Content type: Review Published on:

  27. Chimeric antigen receptor (CAR) T cell therapy is a new cancer immunotherapy targeting cancer-specific cell surface antigen. CD19-CAR T cells have been already shown to be very effective to B cell leukemia/lym...

    Authors: Kana Hasegawa and Naoki Hosen
    Citation: Inflammation and Regeneration 2019 39:10
    Content type: Review Published on:

  29. During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell...

    Authors: Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi and Nobuyuki Takakura
    Citation: Inflammation and Regeneration 2019 39:9
    Content type: Research article Published on:

  30. Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, ...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Shinsuke Ikeno, Hitomi Taniura, Masayoshi Kurono, Keito Minemori, Yu Katsuyama and Hayato Naka-Kaneda
    Citation: Inflammation and Regeneration 2019 39:8
    Content type: Research article Published on:

  31. TGF-β has an important role in the process of wound healing and scar formation. The aim of this study is to determine the effects of ethanolic and methanolic extracts of Calendula officinalis on the expression of...

    Authors: Maryam Hormozi, Mohammadreza Gholami, Ayda Babaniazi and Anneh Mohammad Gharravi
    Citation: Inflammation and Regeneration 2019 39:7
    Content type: Research article Published on:

  32. T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are compos...

    Authors: Ryunosuke Muro, Hiroshi Takayanagi and Takeshi Nitta
    Citation: Inflammation and Regeneration 2019 39:6
    Content type: Review Published on:

  33. Tumor necrosis factor inhibitor therapy for rheumatoid arthritis (RA) patients reduces disease activity, but little is known about the factors that correlate with continuation of remission. To identify demogra...

    Authors: Noriko Kimura, Katsuya Suzuki and Tsutomu Takeuchi
    Citation: Inflammation and Regeneration 2019 39:5
    Content type: Research article Published on:

  35. Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses. In inflammatory microenvironments, mac...

    Authors: Kentaro Maruyama, Eiji Nemoto and Satoru Yamada
    Citation: Inflammation and Regeneration 2019 39:3
    Content type: Review Published on:

  36. Finding the best dressing for a specific wound had continued from the past to present. The aim of this study was to evaluate the effect of encapsulated extract of Satureja khuzistanica in hydrogel alginate at wou...

    Authors: Fatemeh Beyranvand, Ahmad Gharzi, Abolfazl Abbaszadeh, Reza Mohammadrezaei Khorramabadi, Mohammadreza Gholami and Anneh Mohammad Gharravi
    Citation: Inflammation and Regeneration 2019 39:2
    Content type: Research article Published on:

  39. Periodontopathic bacteria such as Porphyromonas gingivalis produce a large amount of butyric acid as a metabolite. Though butyric acid has been reported to have an anti-inflammatory effect on inflammatory disease...

    Authors: Michihiro Shirasugi, Maki Nakagawa, Keisuke Nishioka, Toshiro Yamamoto, Takaaki Nakaya and Narisato Kanamura
    Citation: Inflammation and Regeneration 2018 38:23
    Content type: Review Published on:

  43. In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a cas...

    Authors: Maho Nakazawa, Katsuya Suzuki, Hidekata Yasuoka, Kunihiro Yamaoka and Tsutomu Takeuchi
    Citation: Inflammation and Regeneration 2018 38:20
    Content type: Case report Published on:

  44. Alzheimer’s disease is a neurodegenerative disease characterized by the interstitial deposition of amyloid β (Aβ) plaque, which is thought to be related to chronic neuroinflammation. Aβ is known to make fibril...

    Authors: Ayaka Nakanishi, Naoe Kaneko, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Wei Zhou, Mie Kurata, Toshihiro Yamamoto, Sheikh Mohammad Fazle Akbar, Tamotsu Zako and Junya Masumoto
    Citation: Inflammation and Regeneration 2018 38:27
    Content type: Research article Published on:

  45. In the era of precision medicine, transcriptome analysis of whole gene expression is an essential technology. While DNA microarray has a limited dynamic range and a problem of background hybridization, RNA seq...

    Authors: Shuji Sumitomo, Yasuo Nagafuchi, Yumi Tsuchida, Haruka Tsuchiya, Mineto Ota, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Keishi Fujio and Kazuhiko Yamamoto
    Citation: Inflammation and Regeneration 2018 38:21
    Content type: Review Published on:

  47. Mitochondria regulate not only cell functions through energy generation but also aging-associated cell phenotypes. Impaired mitochondrial structural and functional integrity accompanied by excessive mitochondr...

    Authors: Kazuya Tsubouchi, Jun Araya and Kazuyoshi Kuwano
    Citation: Inflammation and Regeneration 2018 38:18
    Content type: Review Published on:

  48. Stem cell-based cardiac regenerative therapy is expected to be a promising strategy for the treatment of severe heart diseases. Pluripotent stem cells enabled us to reconstruct regenerated myocardium in injure...

    Authors: Hidetoshi Masumoto and Jun K. Yamashita
    Citation: Inflammation and Regeneration 2018 38:26
    Content type: Review Published on:


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Inflammation and Regeneration

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