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  1. We previously reported that a vascular endothelial stem cell population resides in pre-existing blood vessels in mice and may contribute to vascular endothelial cells in liver injury or hind limb ischemia mode...

    Authors: Ami Takii, Yukika Tanabe, Wenting Li, Hiroki Shiomi, Akane Inoue, Fumitaka Muramatsu, Weizhen Jia and Nobuyuki Takakura
    Citation: Inflammation and Regeneration 2025 45:14
    Content type: Research article Published on:

  2. Aging-associated dysbiosis leads to chronic inflammation and the development of a range of aging-related diseases. The gut microbiota crosstalks with the host by providing lipid metabolites and modulating meta...

    Authors: Tomoaki Ishihara, Hiroshi Tsugawa, Seigo Iwanami, Jen-Chien Chang, Aki Minoda and Makoto Arita
    Citation: Inflammation and Regeneration 2025 45:13
    Content type: Research article Published on:

  3. The clinical application of mesenchymal stem cells (MSCs) has garnered attention due to their remarkable capacity to differentiate into adipocytes, chondrocytes, and osteoblasts. However, the quality of MSC cu...

    Authors: Kotaro Tanaka, Rintaro Yoshikawa, Satoru Miyagi, Takashi Suyama, Hiromi Miyauchi, Yuko Kato, Kenichi Miyamoto and Yumi Matsuzaki
    Citation: Inflammation and Regeneration 2025 45:12
    Content type: Research article Published on:

  4. Peripheral nerve injuries (PNI) occur in approximately 13–23 per 100,000 individuals, predominantly affecting young and middle-aged adults. These injuries often require a lengthy recovery period, placing subst...

    Authors: Fangyuan Wang, Chenglin Zhao, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Wulong Liang, Weihua Hu and Xudong Fu
    Citation: Inflammation and Regeneration 2025 45:11
    Content type: Review Published on:

  5. Wound healing is a complex physiological process essential for restoring tissue integrity following various injuries, ranging from minor, everyday incidents to post-surgical complications. Emerging studies hav...

    Authors: Dong-Yeon Kim, Tae-Sung Lee, Yun-Ji Lee, So-Yeon Ahn, Byeongsam Chu, Do-Hyeon Jung, Yeong-Jun Kim, In-Su Seo, Wan-Gyu Kim, Young Jin Cho, Jung Joo Hong and Jong-Hwan Park
    Citation: Inflammation and Regeneration 2025 45:10
    Content type: Research article Published on:

  6. Ectopic fat is also formed in muscles as well as the liver, where adipose-derived mesenchymal stem cells (ADSCs) promote adipogenesis. On the other hand, after muscle injury, muscle satellite cells (SCs) contr...

    Authors: Takashi Otsuka, Kaoru Yamagata, Mai-Phuong Nguyen, Uyen Thi Ngo, Hidenori Sakai, Gulzhan Trimova, Junpei Anan, Yosuke Okada, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2025 45:9
    Content type: Research article Published on:

  7. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to severe coronavirus disease 2019 (COVID-19), which is characterized by cytokine storm and organ dysfunction. The spike S1 subun...

    Authors: Teruaki Murakami, Yuta Yamaguchi, Saori Amiya, Yuko Yoshimine, Shinichiro Nameki, Yasutaka Okita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Atsushi Kumanogoh and Takayoshi Morita
    Citation: Inflammation and Regeneration 2025 45:8
    Content type: Research article Published on:

  8. Ischemic stroke triggers inflammation that promotes neuronal injury, leading to disruption of neural circuits and exacerbated neurological deficits in patients. Immune cells contribute to not only the acute in...

    Authors: Koshi Irisa and Takashi Shichita
    Citation: Inflammation and Regeneration 2025 45:7
    Content type: Review Published on:

  9. Spatial transcriptomics is a cutting-edge technology that analyzes gene expression at the cellular level within tissues while integrating spatial location information. This concept, which combines high-plex RN...

    Authors: Atsuko Tsujii Miyamoto, Hiroshi Shimagami, Atsushi Kumanogoh and Masayuki Nishide
    Citation: Inflammation and Regeneration 2025 45:6
    Content type: Review Published on:

  11. Recent evidence suggests that clonally expanded cytotoxic T cells play a role in various autoimmune diseases. Late-onset rheumatoid arthritis (LORA) exhibits unique characteristics compared to other RA forms, ...

    Authors: Mitsuhiro Akiyama, Sohma Wakasugi, Keiko Yoshimoto, Koichi Saito, Sho Ishigaki, Risa Inukai, Yoshiyuki Matsuno, Waleed Alshehri, Yasushi Kondo and Yuko Kaneko
    Citation: Inflammation and Regeneration 2025 45:4
    Content type: Research article Published on:

  12. The incidence of periodontitis is high in older individuals. However, its impact on multi-organ frailty remains unclear. We developed mouse models with varying severity and duration of periodontitis to examine...

    Authors: Yoshitaka Kase, Satoru Morikawa, Yuji Okano, Tatsuya Hosoi, Takazumi Yasui, Yoko Taki-Miyashita, Mitsutaka Yakabe, Maraku Goto, Kazuyuki Ishihara, Sumito Ogawa, Taneaki Nakagawa and Hideyuki Okano
    Citation: Inflammation and Regeneration 2025 45:3
    Content type: Research article Published on:

  13. For the treatment of liver fibrosis, several novel cell therapies have been proposed. Autologous macrophage therapy has been reported as one of the promising treatments. So far, most studies have used colony-s...

    Authors: Yuichi Igarashi, Haruka Wada, Masato Muto, Ryohei Sone, Yoshinori Hasegawa and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2025 45:2
    Content type: Research article Published on:

  14. Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders characterized by immune cell infiltration of muscle tissue accompanied by inflammation. Treatment of IIMs is challenging, with few ...

    Authors: Akiko Nishidate, Kana Takemoto, Yuki Imura, Mikako Murase, Ryu Yamanaka, Manami Kikuchi, Junpei Anan, Sayuka Kato, Airi Akatsuka, Sachiko Mochizuki and Yuzo Koda
    Citation: Inflammation and Regeneration 2025 45:1
    Content type: Research article Published on:

  15. Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) act together to regulate blood pressure and systemic blood flow by appropriately adjusting blood vessel diameter in response to biochemical or b...

    Authors: Yoshiaki Suzuki, Wayne R. Giles, Gerald W. Zamponi, Rubii Kondo, Yuji Imaizumi and Hisao Yamamura
    Citation: Inflammation and Regeneration 2024 44:50
    Content type: Review Published on:

  18. Macrophages and mesenchymal stem cells (MSCs) engage in crucial interplay during inflammation and have significant roles in tissue regeneration. Synovial MSCs, as key players in joint regeneration, are known t...

    Authors: Hayato Kodama, Kentaro Endo and Ichiro Sekiya
    Citation: Inflammation and Regeneration 2024 44:47
    Content type: Research article Published on:

  21. Keloids are currently challenging to treat because they recur after resection which may affect patients’ quality of life. At present, no universal consensus on treatment regimen has been established. Thus, fin...

    Authors: Yining Liu, Wei Zhang, Nan Lin, Zelei Yang, Yanxin Liu and Huaxia Chen
    Citation: Inflammation and Regeneration 2024 44:44
    Content type: Research article Published on:

  22. Acetaminophen (APAP)-induced liver injury is the most common cause of acute liver failure. Macrophages are key players in liver restoration following APAP-induced liver injury. Thromboxane A2 (TXA2) and its recep...

    Authors: Mina Tanabe, Kanako Hosono, Atsushi Yamashita, Yoshiya Ito, Masataka Majima, Shuh Narumiya, Chika Kusano and Hideki Amano
    Citation: Inflammation and Regeneration 2024 44:43
    Content type: Research article Published on:

  24. The neural and immune systems sense and respond to external stimuli to maintain tissue homeostasis. These systems do not function independently but rather interact with each other to effectively exert biologic...

    Authors: Mayuko Izumi, Yoshimitsu Nakanishi, Sujin Kang and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2024 44:41
    Content type: Review Published on:

  25. The transplantation of human mesenchymal stromal/stem cells (hMSCs) has potential as a curative and permanent therapy for congenital skeletal diseases. However, the self-renewal and differentiation capacities ...

    Authors: Yuko Kato, Yusuke Ohno, Ryoji Ito, Takeshi Taketani, Yumi Matsuzaki and Satoru Miyagi
    Citation: Inflammation and Regeneration 2024 44:40
    Content type: Rapid communication Published on:

  26. Skeletal muscle possesses remarkable regenerative capabilities, fully recovering within a month following severe acute damage. Central to this process are muscle satellite cells (MuSCs), a resident population ...

    Authors: Woo Seok Byun, Jinu Lee and Jea-Hyun Baek
    Citation: Inflammation and Regeneration 2024 44:39
    Content type: Review Published on:

  27. Inflammatory respiratory diseases, such as interstitial lung disease (ILD), bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), and respiratory infections, remain significant global health con...

    Authors: Takahiro Kawasaki, Yoshito Takeda and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2024 44:38
    Content type: Review Published on:

  28. Mesenchymal stem/stromal cells (MSCs) are distributed in various tissues and are used in clinical applications as a source of transplanted cells because of their easy harvestability. Although MSCs express nume...

    Authors: Daisuke Hisamatsu, Akimi Ikeba, Taku Yamato, Yo Mabuchi, Mamoru Watanabe and Chihiro Akazawa
    Citation: Inflammation and Regeneration 2024 44:37
    Content type: Note Published on:

  29. Recent single-cell RNA sequencing (scRNA-seq) analysis revealed the functional heterogeneity and pathogenic cell subsets in immune cells, synovial fibroblasts and bone cells in rheumatoid arthritis (RA). JAK i...

    Authors: Nam Cong-Nhat Huynh, Rui Ling, Masatsugu Komagamine, Tianshu Shi, Masayuki Tsukasaki, Kotaro Matsuda, Kazuo Okamoto, Tatsuo Asano, Ryunosuke Muro, Warunee Pluemsakunthai, George Kollias, Yuko Kaneko, Tsutomu Takeuchi, Sakae Tanaka, Noriko Komatsu and Hiroshi Takayanagi
    Citation: Inflammation and Regeneration 2024 44:36
    Content type: Research article Published on:

  30. Mesenchymal stem cells (MSCs) may be effective in treating connective tissue disease and associated organ damage, leveraging their anti-inflammatory and immunoregulatory effects. Moreover, MSCs may possess the...

    Authors: Takuya Kotani, Takashi Saito, Takayasu Suzuka and Shogo Matsuda
    Citation: Inflammation and Regeneration 2024 44:35
    Content type: Review Published on:

  32. Neonatal hypoxic-ischemic brain injury (HIBI) is a significant contributor to neonatal mortality and long-term neurodevelopmental disability, characterized by massive neuronal loss and reactive astrogliosis. C...

    Authors: Miri Kim, Seokmin Oh, Songyeon Kim, Il-Sun Kim, Joowon Kim, Jungho Han, Ji Woong Ahn, Seungsoo Chung, Jae-Hyung Jang, Jeong Eun Shin and Kook In Park
    Citation: Inflammation and Regeneration 2024 44:33
    Content type: Research article Published on:

  33. Extracellular vesicles (EVs) hold the potential for elucidating the pathogenesis of amyotrophic lateral sclerosis (ALS) and serve as biomarkers. Notably, the comparative and longitudinal alterations in the pro...

    Authors: Chris Kato, Koji Ueda, Satoru Morimoto, Shinichi Takahashi, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Daté, Kensuke Okada, Naoki Kobayashi, Jin Nakahara and Hideyuki Okano
    Citation: Inflammation and Regeneration 2024 44:32
    Content type: Research article Published on:

  34. Tobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of insulin-like growth factor 2 (IGF2) in response to lung injury by tobacco carcino...

    Authors: Hye-Jin Boo, Hye-Young Min, Heung-Bin Lim, Euni Lee and Ho-Young Lee
    Citation: Inflammation and Regeneration 2024 44:31
    Content type: Research article Published on:

  35. The chemokine CX3CL1 has been reported to play an important role in optic nerve protection, but the underlying mechanism is still unclear. CX3CR1, the only receptor of CX3CL1, is specifically expressed on reti...

    Authors: Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu, Yumeng Zhang, Yanzhi Guo, Ping Huang, Shouyue Huang and Yisheng Zhong
    Citation: Inflammation and Regeneration 2024 44:30
    Content type: Research article Published on:

  36. Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheles...

    Authors: Haruka Tsuchiya, Mineto Ota, Haruka Takahashi, Hiroaki Hatano, Megumi Ogawa, Sotaro Nakajima, Risa Yoshihara, Tomohisa Okamura, Shuji Sumitomo and Keishi Fujio
    Citation: Inflammation and Regeneration 2024 44:29
    Content type: Research article Published on:

  37. Cellular senescence is the state in which cells undergo irreversible cell cycle arrest and acquire diverse phenotypes. It has been linked to chronic inflammation and fibrosis in various organs as well as to in...

    Authors: Yuki Saito, Sena Yamamoto and Takako S. Chikenji
    Citation: Inflammation and Regeneration 2024 44:28
    Content type: Review Published on:

  38. Regeneration of injured tissue is dependent on stem/progenitor cells, which can undergo proliferation and maturation processes to replace the lost cells and extracellular matrix (ECM). Bone has a higher regene...

    Authors: Yifan Qing, Takehito Ono, Yukihiro Kohara, Atsushi Watanabe, Noboru Ogiso, Masako Ito, Tomoki Nakashima and Sunao Takeshita
    Citation: Inflammation and Regeneration 2024 44:27
    Content type: Research article Published on:

  40. Extracellular vesicles (EVs) derived from dental pulp mesenchymal stem cells (DP-MSCs) are a promising therapeutic option for the treatment of myocardial ischemia. The aim of this study is to determine whether...

    Authors: Elena Amaro-Prellezo, Marta Gómez-Ferrer, Lusine Hakobyan, Imelda Ontoria-Oviedo, Esteban Peiró-Molina, Sonia Tarazona, Pedro Salguero, Amparo Ruiz-Saurí, Marta Selva-Roldán, Rosa Vives-Sanchez and Pilar Sepúlveda
    Citation: Inflammation and Regeneration 2024 44:25
    Content type: Research article Published on:

  41. It is known that maternal immunoglobulins (Igs) are transferred to the offspring across the placenta. However, receiving maternal Igs, especially before the blood–brain barrier (BBB) is formed in the offspring...

    Authors: Keiko Morimoto, Rikuo Takahashi, Goro Takahashi, Michio Miyajima and Kazunori Nakajima
    Citation: Inflammation and Regeneration 2024 44:24
    Content type: Research article Published on:

  42. Cancer tissues contain a wide variety of immune cells that play critical roles in suppressing or promoting tumor progression. Macrophages are one of the most predominant populations in the tumor microenvironme...

    Authors: Takahiro Matsui, Seiji Taniguchi and Masaru Ishii
    Citation: Inflammation and Regeneration 2024 44:23
    Content type: Review Published on:

  43. Carbohydrate sulfotransferase 15 (CHST15) is an enzyme biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated the efficacy of add-on submucosal injections of GUT-1, the RNA oli...

    Authors: Kenji Suzuki, Yukinori Sameshima, Junji Yokoyama, Shuji Terai, Hiroyuki Yoneyama, Raja Atreya, Markus F. Neurath, Toshifumi Hibi and Hitoshi Asakura
    Citation: Inflammation and Regeneration 2024 44:22
    Content type: Research article Published on:

  45. In recent years, immunotherapy has become a standard cancer therapy, joining surgery, chemotherapy, and radiation therapy. This therapeutic approach involves the use of patient-derived antigen-specific T cells or...

    Authors: Sota Kurihara, Akihiro Ishikawa and Shin Kaneko
    Citation: Inflammation and Regeneration 2024 44:20
    Content type: Review Published on:

  49. Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by retarded alveolarization. Tenascin-C (TN-C), an extracellular matrix glycoprotein and soluble molecule, is involved in tissue morphog...

    Authors: Wei Liu, Yu Mao, Qianru Lv, Keyu Lu, Chunyu Yin, Rui Cheng and Mingshun Zhang
    Citation: Inflammation and Regeneration 2024 44:16
    Content type: Research article Published on:

  50. Cancer cell therapy, particularly chimeric antigen receptor (CAR) T-cell therapy for blood cancers, has emerged as a powerful new modality for cancer treatment. Therapeutic cells differ significantly from conv...

    Authors: Noyuri Zama and Satoshi Toda
    Citation: Inflammation and Regeneration 2024 44:15
    Content type: Review Published on:


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Inflammation and Regeneration

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